Astrogliosis: Glial Perspective of Autism Spectrum Disorders
Fatma Sabukazan1, Oytun Erbaş1
1ERBAS Institute of Experimental Medicine, Illinois, USA & Gebze, Türkiye
Keywords: Astrocyte, autism spectrum disorder, glial cell, neuron
Abstract
To date, the cellular mechanisms underlying autism spectrum disorders (ASDs) have not been fully understood. However, various genetic and environmental factors contribute to the etiology of this developmental disorder. Astrocytes are abundant glial cells that perform various functions in health and disease in the central nervous system. Astrocyte dysfunction is found in many diseases, including multiple sclerosis, Alzheimer's disease, Parkinson's disease, Huntington's disease, and neuropsychiatric disorders. Increasing evidence suggests that astrocytes play an important role in synapse maturation and function, and there is evidence of deficiencies in glial cell function in ASD, suggesting a link between astrocytes and autism. The aim of this review is to understand astrocyte functions and their contribution to ASD.
Cite this article as: Sabukazan F, Erbaş O. Astrogliosis: Glial Perspective of Autism Spectrum Disorders. JEB Med Sci 2023;4(1):45-51.
The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.
The authors received no financial support for the research and/or authorship of this article.