Ecren Büyükada1, Ejder Saylav Bora2, İlknur Altuntaş3, Oytun Erbaş3

1Afyon Kocatepe University, Faculty of Science, Department of Molecular Biology and Genetics, Afyonkarahisar, Türkiye
2İzmir Atatürk Research and Training Hospital Emergency Medicine, İzmir, Türkiye
3ERBAS Institute of Experimental Medicine, Illinois, USA & Gebze, Türkiye

Keywords: Bipolar disorder, depression, endoplasmic reticulum, major depressive disorder, psychiatric disorders, unfolded protein response


Endoplasmic reticulum (ER) is an organelle in eukaryotic cells that has specific functions and tasks. Any disruption or abnormality in these functions and tasks can lead to misfolding or inability to fold proteins, causing stress in the cell. The response of ER to overcome this stress is called the unfolded protein response (UPR). The components of the UPR, such as activating transcription factor 6, protein kinase-like ER kinase, and inositol-requiring enzyme 1 alpha, work together to mitigate or remove the stress within the ER. It has a significant role in psychiatric disorders such as bipolar disorder, schizophrenia, major depressive disorder, autism, anxiety, post-traumatic stress disorder, and depression. This role has been investigated from the past to the present, and significant clinical findings have been obtained. This review aims to provide information by addressing both the relationship between neurodegenerative disorders and ER and the relationship between psychiatric disorders and ER.

Cite this article as: Büyükada E, Bora ES, Altuntaş İ, Erbaş O. Endoplasmic Reticulum Stress: Implications for Psychiatric Disorders. JEB Med Sci 2023;4(1):37-44.

Conflict of Interest

The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.

Financial Disclosure

The authors received no financial support for the research and/or authorship of this article.


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