Use of Clozapine in the Treatment-Resistant Schizoprenia
Oğuzhan Kütük
Department of Psychology, Bingöl University, Bingöl, Turkey
Keywords: 5HT-2A antagonism, clozapine, D2 receptor, first and second generation antipsychotics; schizophrenia
Abstract
Clozapine is one of the new antipsychotic drugs. After its emergence, it has been widely used in schizophrenia patients. The mechanism of action of clozapine has made it a gold standard, particularly in the treatment of resistant schizophrenia. This is achieved by its effect on many receptors in the brain, unlike other atypical antipsychotics. Furthermore, the fact that clozapine reduces suicide attempts in schizophrenics has made it more important than other antipsychotics.
The author declared no conflicts of interest with respect to the authorship and/or publication of this article.
The author received no financial support for the research and/or authorship of this article.