Oğuzhan Kütük

Department of Psychology, Bingöl University, Bingöl, Turkey

Keywords: 5HT-2A antagonism, clozapine, D2 receptor, first and second generation antipsychotics; schizophrenia


Clozapine is one of the new antipsychotic drugs. After its emergence, it has been widely used in schizophrenia patients. The mechanism of action of clozapine has made it a gold standard, particularly in the treatment of resistant schizophrenia. This is achieved by its effect on many receptors in the brain, unlike other atypical antipsychotics. Furthermore, the fact that clozapine reduces suicide attempts in schizophrenics has made it more important than other antipsychotics.

Conflict of Interest

The author declared no conflicts of interest with respect to the authorship and/or publication of this article.

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