Öznur Demirci1, İrem Adar1, Oytun Erbaş1

1ERBAS Institute of Experimental Medicine, Illinois, USA & Gebze, Türkiye

Keywords: Antipsychotics, atypical, extrapyramidal, schizophrenia, typical


Antipsychotics are currently used in many disorders, especially schizophrenia and psychotic disorders. Due to extrapyramidal side effects including weight gain, sexual dysfunction, movement disorders, and development of tolerance, the production of new antipsychotic drugs is a subject that is still being studied. This process, which first started with the discovery of typical antipsychotics, has become widespread with the discovery of atypical antipsychotics after the 90s, and at the same time, the use of antipsychotics in diseases has expanded. This review aims to describe the types of antipsychotics, the physiological mechanisms by which antipsychotic drugs act on the brain, the different side effects of antipsychotic drugs on the brain, and the mechanisms of action of these drugs in various brain disorders as much as possible to express it clearly and understandably.

Cite this article as: Demirci Ö, Adar İ, Erbaş O. An Overview of Antipsychotics: Mechanisms of Action. JEB Med Sci 2023;4(1):62-70.

Conflict of Interest

The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.

Financial Disclosure

The authors received no financial support for the research and/or authorship of this article.