The Role of Serotonin in Breast Cancer

Büşra Nur Barmanbay1, İlknur Altuntaş1, Oytun Erbaş1

1ERBAS Institute of Experimental Medicine, Illinois, USA & Gebze, Türkiye

Keywords: 5-HT, breast cancer, cancer, serotonin

Abstract

Serotonin (5-hydroxytryptamine, 5-HT) is a hormone that functions as a neurotransmitter as well as a hormone. Recently, the link between 5-HT and metabolic diseases has been revealed. Breast cancer is one of the most common cancers in women throughout the world. Serotonin is a monoamine that is produced and secreted by breast epithelial cells. It is essential for maintaining epithelial homeostasis during pregnancy, lactation, and involution. The role of 5-HT in tumor cell biology in breast cancer is not completely understood. In this review, we focused on the impact of 5-HT on breast cancer.

Cite this article as: Barmanbay BN, Altuntaş İ, Erbaş O. The Role of Serotonin in Breast Cancer. JEB Med Sci 2022;3(3):221-226.

Conflict of Interest

The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.

Financial Disclosure

The authors received no financial support for the research and/or authorship of this article.

Acknowledgments

The figure used in this review was created with BioRender (BioRender.com).