Antidepressant Effects of Ketamine
Cengizhan Zerzevatcı1, Raziye Beyza Kılıçoğlu1, Ayşe Safiye Genç1, Oytun Erbaş1
1ERBAS Institute of Experimental Medicine, Illinois, USA & Gebze, Türkiye
Keywords: Antidepressants, depression, ketamine, N-methyl-D-aspartic acid
Abstract
Depression is recognized as a potentially fatal medical condition with far-reaching consequences. Antidepressants are used to treat depression. Ketamine is a short-acting anesthetic and pain reliever that is largely used in veterinary surgery. It is also employed in human medicine, albeit to a lesser extent. It is one of the safest anesthetics because it does not reduce breathing or heart rate. Ketamine has produced a lot of research in the last several years about its usefulness in treating specific mental health issues. But there's still a lot to understand about how ketamine works, how it's dosed, and what long-term consequences it can have on the body. Ketamine is an N-methyl-D-aspartic acid receptor pore blocker, which accounts for the majority of its activities except for the antidepressant effect, the mechanism of which is still being researched and debated. The effects of ketamine as an antidepressant on depression were compared and discussed in this review.
Cite this article as: Zerzevatcı C, Kılıçoğlu RB, Genç AS, Erbaş O. Antidepressant Effects of Ketamine. JEB Med Sci 2022;3(3):227-231.
The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.
The authors received no financial support for the research and/or authorship of this article.