Regulation, Activation, and Function of Caspase-11 in Inflammation
Koray Berk Çiftçi1, Kaan Erbakan1, Alper Demirezen1, Oytun Erbaş1
1ERBAS Institute of Experimental Medicine, Illinois, USA & Gebze, Turkey
Keywords: Caspase-11, high-mobility group box 1 protein, inflammasome, inflammation, sepsis, toll-like receptor 4
Sepsis is the body's physiological response as a result of the passage of infectious bacteria into the bloodstream. In many areas of the body, inflammation damages organs and tissues even though it is essential for the healing of illnesses. Even while the amount of bacteria in the bloodstream plays a major role in determining the severity of sepsis, bacteria type and the pathways they can activate also play a role. In addition to being a protease enzyme, caspase-11 can be activated by a variety of molecular pathways. These pathways consist of a wide range of molecules and receptors including high-mobility group box 1 protein, toll-like receptor 4, receptor for advanced glycation end products-specific receptor, arachidonate 5-lipoxygenase, immunity-related GTPase family M protein, sphingosine-1-phosphate receptor 2, TIR-domain-containing adapter-inducing interferon-β, connexin-43, gasdermin D, NLR family pyrin domain containing 3. There are different paths that might be used in the treatment of septic outcomes caused by infection. In this review, we discussed the significance of the caspase-11, which is crucial to the inflammation brought on by sepsis even though all molecular routes are still poorly known.
Cite this article as: Çiftçi KB, Erbakan K, Demirezen A, Erbaş O. Regulation, Activation and Function of Caspase-11 in Inflammation. JEB Med Sci 2022;3(2):179-184.
The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.
The authors received no financial support for the research and/or authorship of this article.
The Figures (Figure 1 and Figure 2) used in this review were created with BioRender (BioRender.com).