Müzeyyen Aybüke Yayla1, Begüm Arda1, Yaren Kul1, Oytun Erbaş1

1ERBAS Institute of Experimental Medicine, Illinois, USA & Gebze, Turkey

Keywords: Aging, Alzheimer's disease, amyloid precursor protein, circadian rhythm, sleep, stress


Alzheimer's disease (AD), which is an advanced dementia progression, is one of the neurodegenerative disorders that result from the accumulation of amyloid plaques and neurofibrillary tangles in the brain. There are several risk factors that can be caused by AD such as genetic and epigenetic factors. Apart from this, factors such as aging, stress, and sleep disturbance are closely associated with AD. The biological clock also called the circadian rhythm, optimizes the day-night cycle so that living things adapt to their basic needs such as nutrition, sleep, and fertility, as well as external factors such as heat and light from the environment. Disturbances in the circadian rhythm, associated with the melanin hormone, trigger sleep disorders, obesity, cardiovascular diseases, and neurodegenerative disorders. In this review, sleep disorders caused by circadian rhythm disturbance and the relationship between sleep and AD were discussed.

Cite this article as: Yayla MA, Arda B, Kul Y, Erbaş O. Alzheimer's Disease Pathology and Sleep Quality. JEB Med Sci 2022;3(2):173-178.

Conflict of Interest

The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.

Financial Disclosure

The authors received no financial support for the research and/or authorship of this article.