Neuregulin 1 and Its Roles in Schizophrenia: A Systematic Review
Dildar Savcı1
, Sultan Karadeniz1, Oytun Erbaş1
1ERBAS Institute of Experimental Medicine, Illinois, USA & Gebze, Turkey
Keywords: ErbB, neuregulin1 (NRG1), neurodevelopment, schizophrenia
Abstract
Schizophrenia is a complex disease with a multifactorial inheritance model, characterized by self-esteem and thought disorder. Neuregulin 1 (NRG1) gene is among the schizophrenia genetic factors. This gene plays a role in the erythroblastic leukemia viral oncogene homolog (ErbB) signaling pathway and many biological processes. Symptoms of schizophrenia are observed with the impairment of NRG1's function in the ErbB4 signaling pathway. As a result of its overexpression, it is known that there is an important relationship between the dysfunction of N-methyl D-aspartate receptors and schizophrenia. It is also supported by epistasis studies, gene expression studies, studies investigating the relationship between mental state and psychosis, and genotype-phenotype correlation studies. In this review, the connections of the NRG1 gene and schizophrenia were discussed.
Cite this article as: Savcı D, Karadeniz S, Erbaş O. Neuregulin 1 and Its Roles in Schizophrenia: A Systematic Review. JEB Med Sci 2021;2(3):406-413.
The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.
The authors received no financial support for the research and/or authorship of this article.