SOX2 Gene and Tumor Development

Dilek Daşdelen1, Alper Demirezen1, Berfin Sıla Akdoğu1, İlknur Altuntaş1, Oytun Erbaş1

1ERBAS Institute of Experimental Medicine, Illinois, USA & Gebze, Turkey

Keywords: Glioblastoma, SOX2 gene, SRY gene, tumor

Abstract

The sex-determining region Y-box 2 (SOX2) gene plays an important role in both embryonic development and the postnatal period. Mutations that may occur in the SOX2 gene lead to the formation of various defects in the human brain. SOX2 gene has been shown to promote cell proliferation and tumor metastasis in various tumor types such as glioblastomas, colorectal cancer, prostate cancer, breast cancer, and stomach cancer. This article reviewed the functions of the SOX2 gene and its relationship with tumor formation.

Cite this article as: Daşdelen D, Demirezen A, Akdoğdu BS, Altuntaş İ, Erbaş O. SOX2 Gene and Tumor Development. JEB Med Sci 2021;2(3):318-325.

Conflict of Interest

The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.

Financial Disclosure

The authors received no financial support for the research and/or authorship of this article.