Alper Demirezen1, Oytun Erbaş1

1ERBAS Institute of Experimental Medicine, Illinois, USA & Gebze, Turkey

Keywords: CREB, DUSP4, epilepsy, MAPK, seizures


One of the most common degenerative disorders of the neuronal system is epilepsy, a neurodegenerative disorder in which the individual suffers from categorized repetitive seizures in the brain and is linked to the development of various disorders or syndromes. Although the causes of epilepsy are unknown, it has been revealed that epilepsy is induced by the expression of several genes in the relevant molecular pathways. The mitogen-activated protein kinase (MAPK)-cyclic AMP (cAMP) response element-binding protein (CREB) signaling pathway is one of these pathways, and it is also the molecular basis of epileptic permanent seizures in the neocortex region of the human brain. By inhibiting the activation of MAPK, which is involved in the molecular organization of seizures in this part of the brain, the dual-specificity protein phosphatase 4 (DUSP4) protein functions as such an inhibitor. In this review, the roles of protein-based DUSP4, which serves as an inhibitor by reducing the actions of signaling pathways or molecules such as extracellular-signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK), in the molecular organization of epilepsy, epileptic seizures, and epilepsy were examined.

Cite this article as: Demirezen A, Erbaş O. DUSP4 Expression as a Therapeutic Approach for Epilepsy. JEB Med Sci 2021;2(3):289-297.

Conflict of Interest

The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.

Financial Disclosure

The authors received no financial support for the research and/or authorship of this article.