Dilara Kılıç1, Oytun Erbaş1

1ERBAS Institute of Experimental Medicine, Illinois, USA & Gebze, Turkey

Keywords: Gingival crevicular fluid, osteoclast, osteoprotegerin, periodontitis, receptor activator of nuclear factor-kappa B ligand, receptor activator of nuclear factor-kappa B.


Periodontitis is caused by a complex inflammatory over-response, which may be exacerbated by genetic predisposition and environmental factors. Periodontal disease is characterized by the formation of periodontal pockets and the resorption of alveolar bone. The level of bone mass is determined by the balance of bone resorption by osteoclasts and bone formation by osteoblasts. Osteoclasts cause periodontal bone resorption. Receptor activator of nuclear factor-kappa B ligand (RANKL), its receptor activator of nuclear factor-kappa B (RANK), and the decoy receptor osteoprotegerin (OPG) are all key molecules in the regulation of osteoclastogenesis and bone resorption. RANKL/RANK signaling controls the formation of multinucleated osteoclasts from their precursors, as well as their activation and survival during normal bone remodeling. By binding to RANKL and inhibiting its binding to its receptor, RANK, OPG protects the skeleton from excessive bone resorption. This review aimed to investigate variation in the RANKL and OPG levels in the gingival crevicular fluid in periodontal disease.

Cite this article as: Kılıç D, Erbaş O. Osteoprotegerin and RANKL Levels of Gingival Crevicular Fluid in Periodontal Disease. JEB Med Sci 2021;2(3):283-288.

Conflict of Interest

The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.

Financial Disclosure

The authors received no financial support for the research and/or authorship of this article.