mRNA Vaccines

Abstract

Vaccines are solutions made with the aim of providing immunity against diseases by giving the body the attenuated disease virus, parts, or secretions of the disease agent. They are based on the principle that the immune system gives a strong response and eliminates this factor as a result of re-encounter by introducing the disease agent to the immune system and creating an immune memory. Vaccination has lowered the prevalence of many diseases around the world since its inception. One type of vaccine that has emerged in recent years is messenger ribonucleic acid (mRNA) vaccines. mRNA is a nucleic acid molecule that takes part in the production of proteins from deoxyribonucleic acid (DNA). Since it has an important role in protein synthesis, it can be used as a tool to produce the desired protein. With this principle, in mRNA vaccines, a part of the antigen that causes the disease is produced, and this antigen is introduced to the immune system. These vaccines have many advantages and convenience over conventional vaccines, as well as certain difficulties. mRNA vaccines can be used to prevent viral pandemics as well as bacterial pathogens. At the same time, mRNA vaccines have been produced for cancer treatment in recent years. In this review, how vaccines stimulate the immune system, from the types of mRNA vaccines, how they are produced and used; advantages, disadvantages, clinical use of these vaccines, and some current studies on mRNA vaccines were mentioned.

Cite this article as: Selen Mutlu Z, Üzümcü İ, Erbaş O. mRNA Vaccines. JEB Med Sci 2021;2(2):267-273.

The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.

The authors received no financial support for the research and/or authorship of this article.