Hard Physical Work and Alzheimer’s Disease Risk

Abstract

Alzheimer’s disease (AD) is the most common reason for dementia. Observable symptoms are unmissable, such as deteriorating memory, psychiatric disturbances, corruption of neurological functions. Factors that affect and create AD are commonly studied but rarely understood. However, indicators such as sleep, stress, eating habits, physical activity habits, and work environment (occupational physical activity) have been worked on and confirmed by scientific research. Tau protein and amyloid β-protein (Aβ) have been associated with the pathology of AD in the brain. Also, AQP4 polarization and AD relation are based upon the accumulation of unwanted structures such as tangle and plaque formations. On the other hand, the brain's clearance system, which is linked to bodily ailments such as cardiovascular problems and blood circulation, has been identified as a significant factor in brain health because any activity that affects circulation has the potential to link brain health, dementia, and AD. It has been observed that Leisure time physical activity (LTPA) such as planned physical activity (fitness, aerobic) is related to preventive factors for AD. Nevertheless, occupational physical activity (OPA) which is usually discussed as working time activity and hard physical work has been positioned in a negative field in the effects which are related to AD in past research. All research has been done in recent years. In this review, general factors that affect AD and the relational base of these factors will be discussed from the OPA and LTPA point of view.

Cite this article as: Yahşi F, Erbaş O. Hard Physical Work and Alzheimer’s Disease Risk. JEB Med Sci 2021;2(2):229-239.

The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.

The authors received no financial support for the research and/or authorship of this article.