Caner Karabaşoğlu1, Berzah Güneş1, Oytun Erbaş1,2

1ERBAS Institute of Experimental Medicine, Illinois, USA & Gebze, Turkey
2Department of Physiology, Medical Faculty of Demiroğlu Bilim University, Istanbul, Turkey

Keywords: Brain-derived neurotrophic factor, dopaminergic system, genetics of suicide, HPA axis, serotonergic system, suicide.


Suicide is a health problem in which the individual ends his/her life voluntarily. It is a phenotype composed of environmental and genetic factors. The suicidal tendency of the individual is due to bipolar disorder, schizophrenia, stress, etc. It is associated with psychological ailments. These are known as environmental factors. The suicidal tendency of the individual also depends on genetic factors. Serotonin and dopamine are neurotransmitters that directly affect human mood. The serotonergic system and dopaminergic system regulate serotonin and dopamine, respectively. The hypothalamic-pituitary-adrenal (HPA) axis is a neuroendocrine structure that regulates stress responses in the body and has a great impact on human psychology. The BDNF protein, also known as a brain-derived neurotrophic factor, provides neuronal development and growth and has an important role in the nervous system. n this article, the function of 5-HTT, TPH-1 and MAOA genes, which are some of the genes belonging to the serotonergic system, the COMT gene, which is one of the genes of the dopaminergic system, the FKBP5 and CRHBP genes belonging to the HPA axis, and the BDNF gene encoding the BDNF relationship has been examined.

Cite this article as: Karabaşoğlu C, Güneş B, Erbaş O. Suicide-Related Genes. JEB Med Sci 2021;2(1):18-26.

Conflict of Interest

The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.

Financial Disclosure

The authors received no financial support for the research and/or authorship of this article.