Effects of Human Genetic Factors (Ethnicity and Race) on Clinical Severity of SARS-CoV-2 (COVID-19)

İbrahim Gökçe1, Kader Aydemir1, Serhat Ayan1, İlknur Altuntaş1, Oytun Erbaş1,2

1ERBAS Institute of Experimental Medicine, Illinois, USA & Gebze, Turkey
2Department of Physiology, Medical Faculty of Demiroğlu Bilim University, Istanbul, Turkey

Keywords: African Americans, Arab, Armenian, Asian, Black, COVID-19, ethnicity, genetic, Hispanic, Jewish, Race, SARS-CoV-2, Turkish, white

Abstract

Coronavirus Disease-19 (COVID-19) which is caused by SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2) has been declared as a pandemic by the World Health Organization (WHO) on 11 March 2020. After the declaration, SARS-CoV-2 took its place in the scientific area. It is a striking fact about COVID-19 pandemic that mortality, morbidity, and severity of the infection differ from region to region and even from country to country. The reason for this case is that interaction between COVID-19 and human cell receptors, inflammation, complement, and coagulation responses in humans differs as a consequence of ethnicity and genetic diversity. In this review, the effects of gene variations dependent on ethnicity on the clinical course of SARS-CoV-2 is aimed to analyze.

Conflict of Interest

The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.

Financial Disclosure

The authors received no financial support for the research and/or authorship of this article.