Glioblastoma Drug Treatments and Animal Models
Emine Yıldız1, Özüm Atasoy2, Oytun Erbaş1,3
1ERBAS Institute of Experimental Medicine, Illinois, USA & Gebze, Turkey
2Department of Radiation Oncology, Kartal City Hospital, Istanbul, Turkey
3Department of Physiology, Medical Faculty of Demiroğlu Bilim University, Istanbul, Turkey
Keywords: Glia, glioblastoma, neuron
Abstract
Glioblastoma is a malignant tumor that is seen in the cerebral hemispheres, cerebellum, spinal cord and brain stem. This tumor, which follows an invasive approach, consists of the cells called astrocytes that form the most important part of the glia cells. When the disease arises, the neurons are directly affected and neurotransmitter substances cannot fulfill their functions, as well as a memory damage may occur. Studies have been conducted on experimental animals in order to perform better analysis in the treatment for years. As a result of studies on rat and mouse models, it has been proven that drugs such as irinotecan, bevacizumab, temozolomide and their active ingredients are promising for patients. In this review, it is aimed to reveal how glioblastoma emerged, its diseases and symptoms by working step by step on animal models of rats and mice, and to expand the field of drug treatment.
The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.
The authors received no financial support for the research and/or authorship of this article.