Alper Demirezen1, Oytun Erbaş1

1ERBAS Institute of Experimental Medicine, Illinois, USA & Gebze, Türkiye

Keywords: Cancer, cancer stem cells, cancer treatment, tumor-initiating cells.

Abstract

Many investigations have been conducted on how cancer develops and how to cure it over the years since the diagnosis of the disease first appeared in medical history. On the basis of securities therapies, numerous treatment modalities have been suggested. The expression of cancer stem cells (CSCs) is a result of the malignant tumor’s complete disappearance and propensity to reappear. Self-renewal is the primary hallmark of CSCs. This characteristic explains why to stem cells and cancer cells share some characteristics. Cancer stem cells are hypothesized to be the cause of aggressive, recurring cancers that are resistant to chemotherapy. The study of cell biology in medicine has grown in recent years. Particularly, CSCs are believed to be crucial to tumor spread. Future research will therefore develop medicines that target CSCs for the treatment of cancer by determining the prognosis. This chapter explores the definition and historical background of cancer, along with the definition, history, metabolic features, and other characteristics of CSCs. Additionally, it examines the role of CSCs in conventional cancer treatments.

Cite this article as: Demirezen A, Erbaş O. Cancer Stem Cells. JEB Med Sci 2024;5(1):144-151.

Conflict of Interest

The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.

Financial Disclosure

The authors received no financial support for the research and/or authorship of this article.