Sinem Adalı1, Oytun Erbaş1

1ERBAS Institute of Experimental Medicine, Illinois, USA & Gebze, Türkiye

Keywords: Endoplasmic reticulum, endoplasmic reticulum stress, key proteins (XBP, elF2, ATF4, CHOP), neurodegenerative disorders, unfolded protein response


The endoplasmic reticulum (ER) is a crucial organelle involved in protein folding and maintaining cellular homeostasis. Disruptions in these processes lead to ER stress, triggering the unfolded protein response (UPR). It is regulated by key proteins such as X-box binding protein 1, eukaryotic initiation factor 2, activating transcription factor 4, and C/EBP homologous protein. Emphasizes the importance of ER stress and these key proteins in cellular biology and disease mechanisms. Endoplasmic reticulum stress and UPR dysregulation have been associated with various diseases, including neurodegenerative disorders, diabetes, and cardiovascular diseases. Understanding the complex relationship between ER stress, UPR, and disease pathogenesis has the potential to contribute to the development of novel treatment strategies. This review aims to advance our knowledge of cellular biology and enhance our understanding of disease diagnosis and treatment.

Cite this article as: Adalı S, Erbaş O. Cellular Response to Endoplasmic Reticulum Stress: Focus on XBP, elF2, ATF4, and CHOP. JEB Med Sci 2023;4(2):122-133.

Conflict of Interest

The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.

Financial Disclosure

The authors received no financial support for the research and/or authorship of this article.