Neuroinflammatory Mechanisms in Alzheimer's Disease
Gizem Nur Tuncer1, Mai Abusalim1, Oytun Erbaş1
1ERBAS Institute of Experimental Medicine, Illinois, USA & Gebze, Türkiye
Keywords: Alzheimer's disease, amyloid-beta, brain, cytokines, inflammation, neuroinflammation
Abstract
Alzheimer's disease (AD) is a neurodegenerative disorder with an unknown origin, making it difficult to diagnose and treat. The pathological features of AD include extensive loss of neurons, amyloid plaques, and neurofibrillary tangles, among others. Amyloid-beta has been extensively researched, and treatment has been attempted, but with little success in clinical practice. Recently, neuroinflammation has been targeted as a treatment for this disease's progression. The neuroinflammation found in AD patients' brains is associated with several mechanical processes, including cyclooxygenase pathways, cytokines, the complement system, chemokines, and oxidative stress. Oligodendrocytes, microglia, and astrocytes work together among other cells to protect the brain from damage. The review focuses on the neuroinflammatory mechanisms that occur in AD.
Cite this article as: Tuncer GN, Abusalim M, Erbaş O. Neuroinflammatory Mechanisms in Alzheimer's Disease. JEB Med Sci 2022;3(3):239-245.
The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.
The authors received no financial support for the research and/or authorship of this article.