Elif Şentürk1, Hadi Sasani2, Berzah Güneş3, Oytun Erbaş3

1St Helens and Knowsley Teaching Hospitals NHS Foundation Trust, Department of Psychiatry, North West, United Kingdom
2Tekirdağ Namık Kemal University, Faculty of Medicine, Department of Radiology, Tekirdağ, Turkey
3ERBAS Institute of Experimental Medicine, Illinois, USA & Gebze, Turkey

Keywords: Cardiovascular diseases, metabolic syndrome, neurodegenerative disorders, radiology


The metabolic syndrome (MetS) is characterized by the presence of five parameters including dyslipidemia, abdominal (centripetal) obesity, impaired glucose tolerance, insulin resistance and hypertension. The likelihood of a patient having cardiovascular disease (CVD) is increased by all of these factors. Worldwide, its prevalence is higher among people with severe mental illness, possibly as a result of the harmful lifestyles defined by inactivity, heavy drinking, smoking, unhealthful foods, and psychotropic prescription use. Patients in psychiatric facilities run a higher risk of dying too soon, mostly from CVD. There is some proof that mental illnesses and MetS have a bidirectional longitudinal influence and that there is a dose-response relationship between the intensity and duration of symptoms. In general, associations with dyslipidemia dysregulations and abdominal obesity seem greater than those with hypertension. Unhealthy lifestyle choices and poor adherence to prescribed medications, which are common among people with mental health conditions, are contributing factors. The development of MetS and mental disorders is influenced by pleiotropy in genetic susceptibility and pathophysiological processes, such as those causing greater central and peripheral activation of immuno-metabolic or endocrine systems. Imaging is crucial for assessing abdominal obesity as well as for identifying fatty liver or consequences from MetS. In this article, we aimed to review the link between MetS and psychiatric disorders.

Cite this article as: Şentürk E, Sasani H, Güneş B, Erbaş O. The Effects of Metabolic Syndrome on Psychiatric Disorders. JEB Med Sci. 2022;3(2):125-133.

Conflict of Interest

The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.

Financial Disclosure

The authors received no financial support for the research and/or authorship of this article.