Understanding the Role of DISC1 in Psychiatric Disorders
Şeyda Yazıcı1, Hadi Sasani2, Oytun Erbaş1
1ERBAS Institute of Experimental Medicine, Illinois, USA & Gebze, Turkey
2Tekirdağ Namık Kemal University, Faculty of Medicine, Department of Radiology, Tekirdağ, Turkey
Keywords: Bipolar disorder, DISC1, psychiatric disorders, schizophrenia
In a Scottish family with major psychiatric disorders such as bipolar and schizophrenia, the chromosome 1;11 translocation was assumed to be related to schizophrenia. Although this discovery has the potential to shed light on schizophrenia, later research has revealed that disruptedin-schizophrenia 1 (DISC1) gene is not affected in all cases of schizophrenia, and that not all aberrant DISC1 results in schizophrenia.With increased studies relating DISC1 to various mental disorders, it is becoming increasingly necessary to investigate the relationship between functional abnormalities in psychiatric patients and DISC1. DISC1 has been found to be involved in processes that deteriorate in psychiatric disorders, such as cell migration, proliferation, differentiation, mitochondrial transport, neuronal growth, and synaptic transmission control, according to investigations on its mechanism. Although genetic linkage studies have identified DISC1 mutations as a general risk factor for schizophrenia, schizoaffective disorder, bipolar disorder, major depression, and autism spectrum disorders, more research is needed to determine which functions of the protein are responsible for the risk factor. The purpose of the review was to discuss the relationship between DISC-1 and psychiatric disorders.
Cite this article as: Yazıcı Ş, Sasani H, Erbaş O. Understanding the Role of DISC1 in Psychiatric Disorders. JEB Med Sci 2022;3(1):68-78.
The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.
The authors received no financial support for the research and/or authorship of this article.