Glutamate Receptor Activity in Neuropsychiatric Disorders
Damla Koyun1, Merve Nur Sevinç1, İlknur Altuntaş1, Oytun Erbaş1
1ERBAS Institute of Experimental Medicine, Illinois, USA & Gebze, Turkey
Keywords: Glutamate, glutamate receptors, neuropsychiatric disorders, receptor mutations
Abstract
Glutamate, a non-essential amino acid, is important for the central mammalian nervous system. It is released into the synaptic cleft from the presynaptic membrane of neurons by vesicles carrying the glutamate protein and is retained by the glutamate receptors of the postsynaptic neuron and takes part in synaptic transmission. Any mutation or change in expression that occurs in the ionotropic and metabotropic receptors, subtypes of glutamate receptors, can cause the development of neuropsychiatric disorders. The aim of the review was to give information about glutamate receptors and their function in psychiatric diseases.
Cite this article as: Koyun D, Sevinç MN, Altuntaş İ, Erbaş O. Glutamat Receptor Activity in Neuropsychiatric Disorders. JEB Med Sci 2022;3(1):54-61.
The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.
The authors received no financial support for the research and/or authorship of this article.