Non-Coding RNAs and Cancer
Manolya Yıldız1, Oytun Erbaş1,2
1ERBAS Institute of Experimental Medicine, Illinois, USA & Gebze, Turkey
2Department of Physiology, Medical Faculty of Demiroğlu Bilim University, Istanbul, Turkey
Keywords: Cancer mechanism, cancer therapy, circRNA, gene expression regulation, lncRNA, miRNA, ncRNA, oncogene, tumor suppressors
Abstract
Non-coding RNAs (ncRNAs) are actively transcribed by regions of the mammalian transcriptome that do not encode proteins. ncRNAs are divided into several groups, the most studied members microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) are identified as important key players in the regulation of gene expression, and they are involved in various cellular processes and disease pathogenesis, including cancer. In recent years, increasing experimental evidence have shown that ncRNAs functions of great importance for cancer mechanisms since they are deeply associated with the oncogenes and tumor suppressor networks. Thus, ncRNAs are identified as potential diagnostic biomarkers and therapeutic targets for cancer diagnosis, prognosis and therapies. In this review, it is aimed to summarize the functional roles of ncRNAs on cancer mechanisms and highlight the promising applications of ncRNAs for cancer treatment.
Cite this article as: Yıldız M, Erbaş O. Non-Coding RNAs and Cancer. JEB Med Sci 2021;2(2):211-217.
The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.
The authors received no financial support for the research and/or authorship of this article.