Transient Receptor Potential (TRP) Channels and Functions
Rumeysa Ekim1, Aylin Kayaaltı1, Oytun Erbaş1,2
1ERBAS Institute of Experimental Medicine, Illinois, USA & Gebze, Turkey
2Department of Physiology, Medical Faculty of Demiroğlu Bilim University, Istanbul, Turkey
Keywords: Biosensor, Ca+2 permeability, sensory physiology, transient receptor potential channels
Abstract
Transient receptor potential (TRP) is the ion channel protein family expressed in plasma membranes in various cell types, including neurons. They are activated by intracellular and extracellular stimuli. TRP proteins have a lot of physiological and pathological roles. They are involved in critical roles in sensory physiology such as vision, smell, hearing, taste, and touch. The TRP gene was first identified in the fruit fly, Drosophila melanogaster, in the late 1960s and the first human homolog was reported in 1995.TRP channels are not selective against cations but have been reported to be highly sensitive to calcium (Ca+2). Different subgroups of the TRP family are structurally varied by means of N and C terminals. TRP family consists of seven groups such as TRPV (Vanilloid), TRPM (Melastatin), TRPC (Canonical), TRPP (Polycystic), TRPA (Ankyrin), TRPML (Mucolipin), and TRPN (Drosophila NOMPC). The eighth TRP family has recently been identified in yeast and named TRPY. In this review, TRP channels, sub-members, and their physiological effects are mentioned.
Cite this article as: Ekim R, Kayaaltı A, Erbaş O. Transient Receptor Potential (TRP) Channels and Functions. JEB Med Sci 2021;2(2):199-205.
The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.
The authors received no financial support for the research and/or authorship of this article.