Chemosensitivity Test
Gamze Erdoğan1, Oytun Erbaş2
1Department of Biology, Ankara University, Faculty of Arts and Sciences, Ankara Turkey
2ERBAS Institute of Experimental Medicine, Illinois USA & Gebze, Turkey
Keywords: Chemosensitivity, chemotherapy, oncogen, tumor suppressor gene
Abstract
Cancer treatment is a fundamental issue that today’s scientists deal with. The use of appropriate chemotherapeutic agents in cancer treatment is still limited by the trial and error methods. Chemosensitivity test is a method that allows choosing the most appropriate treatment for each patient, and its purpose is to directly measure the drug sensitivity of the cells. It is based on the application of various chemotherapeutic agents to the tumor cells in vitro and their cell reproduction. In this way, the most appropriate agent can be selected from the test analyzes including ATP-TCA, MTT, CD-DST, B (SRB). Based on these results, ultimately, most appropriate treatment can be applied. The overexpression of tumor suppressor genes and the silencing of oncogenes are also other parameters that increase chemosensitivity. Here we reviewed briefly the chemosensitivity methods that are used in the medical field as well as the effect of tumor suppressor genes such as P53 and livin on chemosensitivity.
The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.
The authors received no financial support for the research and/or authorship of this article.