The Role of STAT3 in Cancer Development and Progression
Gökçen Kılınç1, Oytun Erbaş2
1University of George Emil Palade, Faculty of Medicine, Târgu Mureș, Romania
2ERBAS Institute of Experimental Medicine, Illinois, USA & Gebze, Türkiye
Keywords: Angiogenesis, cancer stem cells, metastasis, STAT3, oncogenic signaling, tumorigenesis.
Abstract
The signal transducer and activator of transcription 3 (STAT3) is a key member of the STAT family found in the cytoplasm of most mammalian cells. STAT3 is a transient event in normal tissues, but it is activated inappropriately in cancer tissues and is triggered by certain cytokines. This continuous activation regulates the production of downstream proteins implicated in cancer initiation, development, and metastasis. Understanding STAT3 regulation and creating inhibitors targeting the STAT3 pathway are viable cancer treatment strategies. This review addresses the history, scientific advances, and future of the STAT3 pathway in cancer, including STAT3 regulation mechanisms, STAT3-induced cancer hallmarks, new inhibitors, and novel pharmaceutical delivery platforms.
Cite this article as: Kılınç G, Erbaş O. The Role of STAT3 in Cancer Development and Progression. JEB Med Sci 2024;5(4):254-258.
The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.
The authors received no financial support for the research and/or authorship of this article.