The Anxiolytic Effect of Intranasal Drug Administration in Exosomal Form of Oxytocin: Pro-Leu-Gly Amino Acids in Autism Spectrum Disorder

Abstract

Neurological disorders are complex and multifaceted health problems that can affect human life at any age, from infancy to old age. Their cellular mechanisms are complex and intricate. These disorders affect the brain, spinal cord, and nervous system and can significantly alter individuals' social behavior, cognitive abilities, and motor functions. Therefore, individual neurological disorders can have far-reaching effects at the societal level. Autism spectrum disorder (ASD) is a neurodevelopmental disorder that has been characterized by significant challenges in social interactions and repetitive behaviors, it affects approximately one in 100 individuals. The lack of effective treatment creates a substantial gap and leads to new research. Oxytocin (OXT), the neurohormone that is known for its regulative effects on social behavior, can be considered as a potential treatment for decreasing the anxiolytic effects of ASD. This review focuses on the use of OXT’s neuropeptides Proline (Pro), Leucine (Leu), and Glycine (Gly) for minimizing the anxiolytic effects of ASD when applied as exosomes in intranasal form.

Cite this article as: Kocur R, Çetinel A, Erbaş O. The Anxiolytic Effect of Intranasal Drug Administration in Exosomal Form of Oxytocin: Pro-Leu-Gly Amino Acids in Autism Spectrum Disorder. JEB Med Sci 2024;5(3):227-233.

The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.

The authors received no financial support for the research and/or authorship of this article.