Regulatory T Cells and Their Implications in Cancer Immunotherapy
Saime Sıla Gemici1, Oytun Erbaş1
1ERBAS Institute of Experimental Medicine, Illinois, USA & Gebze, Türkiye
Keywords: Cancer, immune response, immunotherapy, regulatory T cells, Treg cells
Abstract
The regulatory T (Treg) cells, an essential cell type in the immune system, control various immune responses, including autoimmune diseases, inflammatory conditions, and cancer. These cells, preventing the development of abnormal immune responses against self-antigens, have complex roles in cancer. Treg cells are abundant in the tumor microenvironment, supporting progression by suppressing anti-tumor immune responses. Ongoing research explores several cancer immunotherapy strategies, including methods aiming to deplete Treg cells. However, the depletion of Treg cells may lead to autoimmune-related adverse events, and investigations into this phenomenon are ongoing. This review examines several strategies developed for cancer immunotherapy.
Cite this article as: Gemici SS, Erbaş O. Regulatory T Cells and Their Implications in Cancer Immunotherapy. JEB Med Sci 2023;4(3):187-191.
The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.
The authors received no financial support for the research and/or authorship of this article.