Avocatin B: Its Role in Cancer and Diabetes Mellitus Treatment
Aslı Melike Ekmekçi1,Arzu Kasabalı1, Oytun Erbaş1
1ERBAS Institute of Experimental Medicine, Illinois, USA & Gebze, Türkiye
Keywords: Acute myeloid leukemia, avocado, avocatin B, cancer, diabetes mellitus, fatty acid oxidant
Abstract
Avocado is at the forefront with its fat-soluble compounds and the phytochemicals it contains, and its health benefits. The odd-numbered carbon lipid, avocatin B (AvoB), obtained from avocado, emerges as an alternative therapeutic approach in epidemic diseases such as cancer and diabetes, with various mitochondrial-focused mechanisms. Avocatin B plays a regulatory role against fatty acid oxidation, transcription factor 4, and free radicals, which are the basis of these diseases. With its functions of lowering blood sugar and increasing insulin sensitivity, AvoB has been shown to have curative effects on diabetes. Since there are limited studies in the literature, it is not clear how to use AvoB routinely. However, it has the potential to be used as an alternative method in the treatment of diseases such as diabetes and cancer in the future. This review aimed to assess the effectiveness of AvoB, a compound identified as having anti-acute myeloid leukemia properties, and investigate the pathways associated with its effects on obesity and diabetes, both of which are diet-related diseases.
Cite this article as: Ekmekçi AM, Kasabalı A, Erbaş O. Avocatin B: Its Role in Cancer and Diabetes Mellitus Treatment. JEB Med Sci 2023;4(1):5-11.
The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.
The authors received no financial support for the research and/or authorship of this article.