Schizophrenia Susceptibility Genes

Abstract

Schizophrenia is an inherited condition, and studies have revealed that environmental influences have a greater genetic effect. Histone modification is related to deoxyribonucleic acid methylation in epigenetics. One of the top potential genes for schizophrenia was thought to be WW domain binding protein 1-like. It also has a significant impact on the polymorphisms of the dopamine receptor (DR) D2 (DRD2) gene. Inconsistent findings have been found regarding the DRD2 gene's C957T and C939T polymorphisms and schizophrenia. The number of genetic variants found in patients with neurological disorders has significantly increased as a result of the quick advancement of sequencing technology. Patients with a variety of neuropsychiatric disorders have a startling number of variations in the glutamate ionotropic receptor N-methyl-D-aspartate (NMDA) type subunit (NMDAR or GRIN) genes that encode the NMDA glutamatergic receptor subunits. The effectiveness of the outcome was specifically assessed by contrasting the clinical and functional effects of genetic variants in (GRIN2A) and GRIN2B with previously published data. The brain contains a large number of DRs, which are important modulators of cognition, motor skills, motivation, and driving. Different receptor activities could be demonstrated in particular neural circuits as a result of the discovery of five genes encoding various DR subtypes. This review discusses genes associated with schizophrenia.

Cite this article as: Akı BN, Erbaş O. Schizophrenia Susceptibility Genes. JEB Med Sci 2022;3(3):191-198.

The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.

The autors received no financial support for the research and/or authorship of this article.