Ayşenur Saygılı1, Oytun Erbaş2

1Inonu University Molecular Biology and Genetics MSc, Malatya, Turkey
2ERBAS Institute of Experimental Medicine, Illinois, USA & Gebze, Turkey

Keywords: Actin, CAPON, exon, NMDA, NOS1AP, schizophrenia, single nucleotide polymorphism (SNP)


Schizophrenia is a mental disorder that affects about 0.5-1% of the general population. The word schizophrenia originated in the Greek language and it comes from the combination of the words "schizo," which means divided (schizein, σχίζειν) and the words "frenos," (phren, φρεν). There are several genes linked to schizophrenia. One of them is the nitric oxide synthase 1 adapter protein (NOS1AP) gene. It shows that excessive expression of long isoform (NOS1AP-L), short isoform (NOS1AP-S) and a novel short isoform (NOS1AP-S’) of NOS1AP alters the actin cytoskeleton and synaptic function. These three isoforms were found to be linked to actin-myosin and N-methyl-D-aspartate receptors. The alteration caused by the mutation in this gene and signal pathways has an influence on schizophrenia. In this review, the link between schizophrenia and NOS1AP was investigated.

Cite this article as: Saygılı A, Erbaş O. Association of NOS1AP Variants in Schizophrenia. JEB Med Sci 2022;3(1):84-89.

Conflict of Interest

The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.

Financial Disclosure

The authors received no financial support for the research and/or authorship of this article.